4 Genes Associated with Increased Risk of Colo-rectal Cancer Identified


An international research team has identified variations in four genes that are linked to an increased risk of colo-rectal cancer.

A team co-led by cancer prevention researcher Ulrike “Riki” Peters, Ph.D., M.P.H., and biostatistician Hsu Li, Ph.D., at Fred Hutchinson Cancer Research Center have been studying the genes linked to colo-rectal cancer through the Genetics and Epidemiology of Colorectal Cancer Consortium. This is a collaboration involving researchers from North America, Australia and Europe who have pooled data from approximately 40,000 study participants, about half of whom have colo-rectal cancer.

4 Genes Associated with Increased Risk of Colo-rectal Cancer

All genetic variants that previously had not been associated with colo-rectal cancer:

  • NABP – a gene involved in DNA repair
  • LAMC1 – the second gene in the laminin gene family found to be associated with colorectal cancer
  • CCND2 – a gene involved in cell-cycle control, which is a key control mechanism to prevent cancer development
  • TBX3 – a gene transcription factor that targets a known colorectal cancer pathway


4 genes associated with increased risk of colorectal cancer identified


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